Reply to Comment on "Sloppy models, parameter uncertainty, and the role of experimental design"
نویسندگان
چکیده
David R. Hagena,b,†, Joshua F. Apgara,b,†,‡, David K. Witmerb,c,†, Forest M. Whitea,d, and Bruce Tidora,b,c,* aDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA bComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA cDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA dDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
منابع مشابه
Comment on "Sloppy models, parameter uncertainty, and the role of experimental design".
We explain that part of the reduction in the parameter uncertainties in the computations of Apgar et al. (Mol. Biosyst. 2010, 6, 1890-900) is due to a greatly increased number of effective data points.
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متن کاملSloppy models, parameter uncertainty, and the role of experimental design.
Computational models are increasingly used to understand and predict complex biological phenomena. These models contain many unknown parameters, at least some of which are difficult to measure directly, and instead are estimated by fitting to time-course data. Previous work has suggested that even with precise data sets, many parameters are unknowable by trajectory measurements. We examined thi...
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عنوان ژورنال:
- Molecular bioSystems
دوره 7 8 شماره
صفحات -
تاریخ انتشار 2011